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Synthesis of unnatural amino acids and other blocks

[Pro9] Substance P

Name
[Pro9] Substance P
Molecular structural formula
Purity
≥95%
CAS Number
104486-69-3
Formula
C66H102N18O13S
MW
1387.73
Target
Neurokinin Receptor
Sequence
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Pro-Leu-Met-NH2
Sequence Shortening
RPKPQQFFPLM-NH2
InChIKey
UFBNSKYNZDUWSN-RZGVDQIZSA-N
References
[1]. Petitet F, et al. Further demonstration that [Pro9]-substance P is a potent and selective ligand of NK-1 tachykinin receptors. J Neurochem. 1991 Mar;56(3):879-89.
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[Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC50 of 0.93 nM.